Successful root canal therapy is centered on the effective debridement and disinfection of the root canal system. Until the introduction of the GentleWave® System, most advances in endodontics have been only incremental, making its disruptive Multisonic Ultracleaning® technology a true breakthrough. Reid V. Pullen, DDS, discusses the various approaches and the associated challenges in endodontic cleaning and disinfection, and how the GentleWave Procedure is changing the landscape of root canal therapy.